Key Scientific Publications about Upsalite®
Investigation of the Antibacterial Effect of Upsalite®
This study presents the first evaluation of the antibacterial properties of the material with mesoporous silica and two other magnesium-containing powder materials used as references. All powder materials in this study are sieved to achieve a particle size distribution between 25 and 75 μm. The Gram-positive bacterium Staphylococcus epidermidis is used as the model bacterium due to its prevalence on human skin, its likelihood of developing resistance to antibiotics, for example, from routine exposure to antibiotics secreted in sweat, and because it is found inside affected acne vulgaris pores. Quantification of bacterial viability using a metabolic activity assay with resazurin as the fluorescent indicator shows that Upsalite® exerts a strong antibacterial effect on the bacteria and that alkalinity accounts for the major part of this effect. The results open up for further development of Upsalite® in on-skin applications where bacterial growth inhibition without using antibiotics is deemed favorable.
Supersaturation of poorly soluble drugs can be achieved with Upsalite®
In an in vitro study published in the European Journal of Pharmaceutical Sciences it is shown that Upsalite® can be used as a drug carrier with the potential to increase bioavailability of drugs that have dissolution rate- or solubility-limited absorption. Upsalite® as a drug carrier that can increase the amount of drug available over time and achieve supersaturation of poorly soluble drugs. Three structurally diverse, poorly water-soluble drugs (celecoxib, cinnarizine and griseofulvin) were successfully loaded in Upsalite® and subsequently rapidly released from this carrier. The use of this drug delivery system allowed us to obtain supersaturation of the test drugs in the studied medium, resulting in significant increases in the total amount of released drug, Cmax and decrease in the time to reach Cmax for all three drugs.
Nanostructure and pore size control of template-free synthesised mesoporous magnesium carbonate
The nanostructure of the Upsalite® is revealed and pore size control was achieved without organic templates or swelling agents. By controlling the pore structure of the material the amorphous phase stabilisation exerted on poorly soluble drug compounds can be tuned and the drug delivery rate can be tailored.
Biocompatibility of Upsalite® in contact with whole human blood
A study presented in RCS Advances further explores the biocompatibility properties of Upsalite® focusing on the interactions with blood. No hemolytic activity was found for Upsalite® upon contact with whole human blood and Upsalite® was found to present anticoagulant properties, most probably due to the uptake of Ca2+.These findings are important and promising for the use of Upsalite® in biomedical applications such as in composites for implant materials where Upsalite® may encounter blood.
First in-vivo biocompatibility study of Upsalite® is published!
Two years ago the award-winning material Upsalite® was discovered by Maria Strømme and her team at the Ångström Laboratory in Uppsala. The material has recently been suggested as a drug delivery vehicle and as a topical bacteriostatic agent. In a just-published study the first in vivo acute systemic toxicity, skin irritation analyses and in vitro cytotoxicity evaluations of Upsalite® are presented.
Upsalite® can control drug release rate
In a study published today in the Journal of Pharmaceutical Sciences that release of pharmaceuticals from Upsalite® can be controlled with great precision by choosing the right size of Upsalite® particles. This means that Upsalite® can be used as a drug carrier not only for poorly soluble drugs, but also for substances where you wish to control the time for the drug release. Sometimes a quick effect from a drug is preferable, for example in the case of headache, and sometimes a slower release of a high dose of a drug is desired to reduce the number of doses or increase the possibility of problematic substances to be absorbed following ingestion of a tablet.
Upsalite® – A Template-Free, Ultra-Adsorbing, High Surface Area Carbonate Nanostructure
We report the template-free, low-temperature synthesis of a stable, amorphous, and anhydrous magnesium carbonate nanostructure with pore sizes below 6 nm and a specific surface area of ∼ 800 m2 g−1, substantially surpassing the surface area of all previously described alkali earth metal carbonates. The moisture sorption of the novel nanostructure is featured by a unique set of properties including an adsorption capacity ∼50% larger than that of the hygroscopic zeolite-Y at low relative humidities and with the ability to retain more than 75% of the adsorbed water when the humidity is decreased from 95% to 5% at room temperature. These properties can be regenerated by heat treatment at temperatures below 100°C.The structure is foreseen to become useful in applications such as humidity control, as industrial adsorbents and filters, in drug delivery and catalysis.